Síntese, caracterização e avaliação da atividade antioxidante in vitro da benzoamidoxima

Abstract

The importance of amidoximes is undeniable due to their wide spectrum of applications both in medicinal chemistry and in the area of materials. Benzoamidoxime, in particular, is an example that presents different biological activities and synthetic and technological applications. From this perspective, this work aimed to synthesize and study its properties. Benzoamidoxime was obtained in the form of a crystalline solid in a yield of 75% through the reaction of benzonitrile with hydroxylamine hydrochloride in the presence of a hydroethanolic solution under an ultrasonic bath. Hydrogen (1HNMR) and carbon (13C NMR) mass spectrometry and magnetic resonance techniques were used to confirm the formation of the product and the data are in agreement with the structure of the compound. The antioxidant capacity of benzoamidoxime was evaluated using the DPPH, ABTS and reducing power methods. The tests revealed a strong antioxidant activity for the different methods tested. Suggesting that this compound has great potential as a drug candidate